MYC protein is a high-risk factor in mantle cell lymphoma and identifies cases beyond morphology, proliferation and TP53/p53 – a Nordic Lymphoma Group study
The transcription factor MYC is a well-described oncogene with an important role in lymphomagenesis, but its significance for clinical outcome in mantle cell lymphoma (MCL) remains to be determined.
The significance of programed cell death-ligand 1 expression in vestibular schwannoma
Published studies report a difference in the PD-L1 positivity rate in malignant peripheral nerve sheath tumors. In this article, the authors examined PD-L1 expression and lymphocyte infiltration in patients with vestibular schwannoma.
Validation of MYC and BCL6 rapid break apart digital fluorescence in situ hybridization assays for clinical use
Detection of gene rearrangements in MYC and human B-cell lymphoma 6 using fluorescence in situ hybridization (FISH) are important in the evaluation of lymphomas, in particular diffuse large B-cell lymphoma and Burkitt lymphoma.
Feasibility and Toxicity of Interval-Compressed Chemotherapy in Asian Children and Young Adults with Sarcoma
The outcome of children and young adults with sarcoma has improved dramatically with the use of systemic chemotherapy in the context of multimodality treatment.
Quantitative Imaging Analysis Fluorescence In Situ Hybridization Validation for Clinical HER2 Testing in Breast Cancer
Quantitative imaging is a promising tool that is gaining wide use across several areas of pathology. This paper demonstrates the utility of quantitative image analysis in providing highly reliable HER2 FISH analysis.
Evaluation of the cytogenetic profile in patients with acute leukaemia
Acute leukaemia is a heterogeneous neoplastic disease that occurs by the growth of abnormal lymphoid and myeloid cells in the bone marrow and blood leading to acute myeloid leukaemia (AML) and acute lymphocytic leukaemia (ALL).
Good Manufacturing Practice compliant change of raw material in the manufacturing process of a clinically used advanced therapy medicinal product a comparability study
The development of medicinal products often continues throughout the different phases of a clinical study and may require challenging changes in raw and starting materials at later stages. Comparability between the product properties pre- and post-change thus needs to be ensured. The increased risk for tumorigenicity potentially associated with the use of human platelet lysate […]
Cytogenetics and Molecular Genetics in Pediatric Acute Lymphoblastic Leukemia (ALL) and Its Correlation with Induction Outcomes
In this article, the authors studied cytogenetics and molecular genetic profile in pediatric B-acute lymphoblastic leukemia (ALL) and correlate it with induction outcomes. G-banded karyotyping was used to assess bone marrow specimens.
Digital imaging correlation of immunohistochemistry and fluorescence in situ hybridization in breast carcinoma cases with HER2 genetic heterogeneity
Genetic heterogeneity is a rare but important event in the evaluation of HER2 amplification status. In this study, the authors investigated whether HER2 fluorescence heterogeneity correlated with increased protein expression by (IHC) and/or morphologic features using image analyses.
The Role of Cytogenetics in Hematolymphoid Malignancies
Join us for an insightful session presented by Dr. Dhanlaxmi Shetty.
This webinar will provide valuable perspectives for clinicians, researchers, and laboratory professionals interested in advancing precision medicine through cytogenetics.
Anti-neoplastic and demethylating activity of a newly synthetized flavanone-derived compound in Renal Cell Carcinoma cell lines
Renal Cell Carcinoma is on the top 10 of the most incident cancers worldwide, being a third of patients diagnosed with advanced disease, for which no curative therapies are currently available.
High Expression of PD-L1 Is Associated with Better Survival in Pancreatic/Periampullary Cancers and Correlates with Epithelial to Mesenchymal Transition
Periampullary cancers are characterized by tumor-infiltrating lymphocytes, severe fibrosis, and epithelial to mesenchymal transition. The immune checkpoint marker programmed death-1 (PD-1) and its ligands 1 and 2 have gained popularity in cancers with TILs.