Digital imaging correlation of immunohistochemistry and fluorescence in situ hybridization in breast carcinoma cases with HER2 genetic heterogeneity

Genetic heterogeneity is a rare but important event in the evaluation of HER2 amplification status. In this study, the authors investigated whether HER2 fluorescence in situ hybridization genetic heterogeneity correlated with increased protein expression by immunohistochemistry (IHC) and/or morphologic features using image analyses.

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