Inactivating TP53 mutations leads to a loss of function of p53, but can also often result in oncogenic gain-of-function (GOF) of mutant p53 proteins which promotes tumor development and progression. Using digital karyotyping among different technologies, the authors found that by targeting mini chromosome maintenance complex components GOF of mutant p53 predisposes cells to replication stress and chromosomal instability.
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https://pubmed.ncbi.nlm.nih.gov/38167338/