Hexavalent Chromium Targets Securin to Drive Numerical Chromosome Instability in Human Lung Cells

Hexavalent chromium is a known human lung carcinogen with widespread exposure in environmental and occupational settings. Despite well-known cancer risks, the molecular mechanisms of Cr(VI)-induced carcinogenesis are not well understood, but a major driver of Cr(VI) carcinogenesis is chromosome instability. Digital karyotyping was one of the techniques used by the authors when establishing centrosome and centromere disruption as key components of numerical chromosome instability.

For the full article – https://pubmed.ncbi.nlm.nih.gov/38203427/