KNOWLEDGE CENTER

Clinical Studies

Screening chronic myeloid leukemia neutrophils using a novel 3-Dimensional Spectral Gradient Mapping algorithm on hyperspectral images

November 8, 2022

A recent study present a novel 3-Dimensional Spectral Gradient Mapping (3-D SGM) method to analyze hyperspectral image cubes of chronic myeloid leukemia (CML) versus healthy blood smears. The study utilized Applied Spectral Imaging (ASI) SpectraView Hyperspectral Imaging System, under the assumption that high spectral and spatial resolution of hyperspectral cellular or tissue images coupled with image analysis algorithms may provide means to detect and diagnose the diseases early on, which is crucial for effective treatment. Study concluded that the new method is efficient and robust for analyzing hyperspectral images of CML versus healthy neutrophils. It has the potential to be developed into an inexpensive, minimally invasive method for screening CML, and could directly facilitate early diagnosis and treatment of the disease.

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Cytogenetics and Molecular Genetics in Pediatric Acute Lymphoblastic Leukemia (ALL) and Its Correlation with Induction Outcomes

September 5, 2022

Dr. Ajeitha Loganathan and her colleagues at the Kanchi Kamakoti Childs Trust Hospital in India have selected Applied Spectral Imaging software to capture and analyse the Metaphases of good morphology in their recent study published in the South Asian Journal of Cancer.

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Defective hematopoietic differentiation of immune aplastic anemia

August 6, 2022

Applied Spectral Imaging (ASI) HiBand, digital chromosome analysis solution was used in a recent study published in “Cell Death and Disease”. The study named “Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs” derived induced pluripotent stem cells (iPSCs) from patients diagnosed with immune Aplastic anemia (AA) who responded to intensive immunosuppressive therapy (IST), had normal-for-age telomeres, and carried no pathogenic variants in inherited AA-related genes by next-generation sequencing, and investigated their hematopoietic differentiation potential and telomere functionality. Study indicate that iPSCs are a reliable platform to model immune AA and recapitulate clinical phenotypes, and propose that the immune attack may cause specific epigenetic changes in the hematopoietic stem and progenitor cells (HSPCs) that limit adequate proliferation and differentiation.

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Comprehensive analysis of genetic factors predicting overall survival in Myelodysplastic syndromes

July 31, 2022

Comprehensive analysis of genetic factors predicting overall survival in Myelodysplastic syndromes. Myelodysplastic syndromes (MDS) are a group of clonal hematological disease with high risk of progression to AML. Genetic lesions (Cytogenetic and Molecular mutations) are known to help in prognosticating the MDS patients. Accurate risk stratification is of importance for the proper management and treatment strategy planning of MDS. digital FISH analysis was carried out using ASI's HiFISH

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Defective hematopoietic differentiation of immune aplastic anemia patient-derived iPSCs

July 13, 2022

ASI HiBand, digital chromosome analysis solution was used in a recent study published in “Cell Death and Disease”. The study derived induced pluripotent stem cells (iPSCs) from patients diagnosed with immune Aplastic anemia (AA) who responded to intensive immunosuppressive therapy (IST), had normal-for-age telomeres, and carried no pathogenic variants in inherited AA-related genes by next-generation sequencing, and investigated their hematopoietic differentiation potential and telomere functionality. Study indicate that iPSCs are a reliable platform to model immune AA and recapitulate clinical phenotypes, and propose that the immune attack may cause specific epigenetic changes in the hematopoietic stem and progenitor cells (HSPCs) that limit adequate proliferation and differentiation.

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